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Peptides: Types, Applications, Advantages & Safety And Security With insulin, one of the primary adverse effects is low blood sugar level while with GLP‑1s, there's a threat of stomach problems. He added that when study is not standard, regulated or evaluated by the FDA, there's no warranty they're being produced safely or that the components are what is marketed. On the other hand, he noted, "insulin and GLP-1s are extremely well researched." Your Partner In Clinical